Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that possesses antipyretic and analgesic properties. The anti-inflammatory effects of naproxen result from the peripheral inhibition of prostaglandin synthesis secondary to inhibition of the enzyme cyclooxygenase.
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that possesses antipyretic and analgesic properties. The anti-inflammatory effects of naproxen result from the peripheral inhibition of prostaglandin synthesis secondary to inhibition of the enzyme cyclooxygenase. Prostaglandins sensitize pain receptors, and their inhibition is believed to be responsible for the analgesic effects.
Pharmacological Class: NSAID
Naproxen is a phenylpropionic acid derivative having analgesic, anti-inflammatory and antipyretic activities. Such activities are thought to be mediated via inhibition of the enzyme complex prostaglandin synthetase with consequent reduction in the synthesis of prostaglandins from arachidonic acid.
Adult dose for
Pediatric dose for
Oral absorption of Naproxen is found to be 100%. Volume of distribution is 0.9 l/kg and plasma protein binding is > 99%. Presystemic metabolism is noted to be 2.5% ±2.5 and metabolism is reported to occur extensively by liver. Renal excretion accounts for 97.5-99% and plasma half life is 12-17 hours.
Common (affecting between 1 in 10 to 1 in 100)
Uncommon (affecting 1 in 100 to 1 in 1000)
Very rare (affecting less than 1 in 10,000)
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