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The precise cause of IBD remains unknown. These diseases are believed to be caused by a combination of genetic and non-genetic, or environmental factors (for example, infections) that interact with the body's immune (defense) system. When the intestinal immune system does not function properly, many white blood cells accumulate in the inner lining (mucosa) of the gut. The white cells then release chemicals that lead to tissue injury (inflammation). This inflammation of the mucosa can cause diarrhea, which is the most common symptom of ulcerative colitis and Crohn's disease, with or without intestinal complications.
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