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Mortality
rates in people with CWP were found to be higher; optimal treatment strategies
should be planned for individuals with CWP.
Premature mortality in persons with chronic
widespread pain (CWP) was not clear. Therefore a large study was conducted to
find out if there is an association between premature mortality in persons with
widespread chronic pain. Along with to determine its magnitude and establish
what factors mediate any relationship.
For this analysis data was taken from the UK Biobank, a cohort of 0.5 million
people of 40 to 69 years of age who were recruited throughout Great Britain
from 2006 to 2010. The participants who reported pain all over the body' for
>3 months were compared with persons without chronic pain. Information on
death (with cause) was available until mid-2015. These results in a
meta-analysis were included with other published reports to calculate a pooled
estimate of excess risk.
The findings showed that about 7130 participants who reported CWP had
experienced excess mortality. The main reason for mortality in excess were
cancer, cardiovascular, respiratory (5.66adjusted age and sex and other
disease-related causes. There was a reduction in the excess risk after
adjusting the low levels of physical activity, high body mass index, poor
quality diet and smoking. The meta-analysis determined that every study showed
significant excess all-cause, cardiovascular and cancer mortality.
Evidence concludes clearly that persons with CWP experience excess mortality.
UK Biobank results considerably reduce uncertainty around the magnitude of
excess risk and are consistent with the excess being explained by adverse
lifestyle factors, which could be targeted in the management of such patients.
Ann Rheum Dis. 2017 Jul 21
Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis
Macfarlane GJ et. al.
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