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Crystal-associated arthritis improved significantly by Anakinra

Crystal-associated arthritis improved significantly by Anakinra Crystal-associated arthritis improved significantly by Anakinra
Crystal-associated arthritis improved significantly by Anakinra Crystal-associated arthritis improved significantly by Anakinra

What's new?

With rapid onset of action and considerable tolerability, Anakinra is a potent therapeutic treatment for acute attacks of gout or CPP crystal arthritis.

Anakinra improves or resolves 75% of episodes of acute gout and calcium pyrophosphate crystal arthritis within four days of the first dose, evident from a retrospective observational study issued in the Journal of Rheumatology.


The analysis comprised patients who treated with Anakinra from 2014-2017. Charts were analysed for laboratory data, comorbidities, demographics, pain scores, concurrent infections, joint involvement, surgical interventions, prior treatment, and dosing and response to Anakinra. Recorded pain scores on a numeric scale and review of provider documentation have defined the response to Anakinra treatment.


A total of 115 episodes of arthritis was identified. Comorbidities occurred with such type of arthritis were the history of organ transplantation and renal disease. Thirty-four episodes found to have a concurrent infection, whereas 29 episodes found in the perioperative setting. Sixty-six episodes exhibited a partial or complete response in just one day, whereas eighty-four episodes showed within four days after the treatment initiation. All patients exhibited well-tolerability toward Anakinra. This most extensive observational study also promotes the application of this biologic agent among people with infections, immunosuppressed transplant recipients, and perioperative individuals.

Source:

The Journal of Rheumatology

Article:

Use of Anakinra in Hospitalised Patients with Crystal-associated Arthritis.

Authors:

Jean W. Liew & Gregory C. Gardner

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