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In patients with non-alcoholic fatty liver disease, phosphatidylcholine treatment reduces levels of transaminase, minimizes the activity of lipid peroxidation markers, and elevates the antioxidant enzymes level.
A prospective pilot study revealed that oral administration of phosphatidylcholine for 3 months is beneficial for the management of non-alcoholic fatty liver disease (NAFLD). Ludovico Abenavoli et al. conducted this study to explore the advantages of phosphatidylcholine intervention in NAFLD patients. A total of 30 participants suffering from NAFLD were recruited and administered 300 mg phosphatidylcholine orally with meals (2 capsules at a time, thrice a day) for 3 months.
A comparison of lab and clinical parameters prior to and post-intervention was done. Following administration of phosphatidylcholine, the level of alanine aminotransferase and aspartate transaminase reduced by 59.6% and 75.4% respectively. Additionally, the level of antioxidant enzymes superoxide dismutase and glutathione peroxidase elevated by 48% and 48.1% respectively after therapy.
To conclude, treatment with phosphatidylcholine yields beneficial outcomes in people diagnosed with NAFLD.
Minerva Gastroenterology
Treatment with phosphatidylcholine of patients with non-alcoholic fatty liver disease: a prospective pilot study
Ludovico Abenavoli et al.
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