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To examine if the use of aspirin is linked with lessened risk of mechanical ventilation, ICU admission, and mortality in the hospital.
COVID-19 is linked with hypercoagulability and higher
thrombotic risk in terminally
ill patients. In this observational
cohort study of 412 COVID-19 patients, the use of aspirin or acetylsalicylic acid was linked with a
significantly decreased mechanical ventilation, intensive care unit (ICU)
admission, and mortality risk following the adjustment for confounding
variables.
To examine if the use of aspirin is linked with lessened
risk of mechanical ventilation, ICU admission, and mortality in the hospital.
Four hundred twelve adult patients admitted with
COVID-19 to multiple hospitals were considered for this study. The requirement
for mechanical ventilation was the primary outcome. ICU admission and mortality
in the hospital were the secondary outcomes.
Apart from 314 patients (76.3%), 98 patients (23.7%) got aspirin within 1 day of the hospital admission or 7 days prior to the admission. Aspirin use had a crude association with reduced mechanical ventilation and ICU admission, but no crude association with mortality as shown in the below table:
Aspirin use was independently linked with lower risk
of mechanical ventilation, ICU admission, and in-hospital mortality after
adjustment for 8 confounding variables. No variations in major bleeding or
overt thrombosis amongst users and non- users of aspirin were found.
Aspirin or acetylsalicylic
acid may be linked with better outcomes in patients
who are hospitalized due to Coronavirus. Future studies are required to
evaluate whether a connecting relationship is present between aspirin use and
decreased lung injury and mortality in patients suffering from COVID-19.
Anesthesia & Analgesia
Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019
Jonathan H. Chow et al.
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