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A non-randomized trial aimed to explore the efficacy of 100 mg nimesulide and 10 mg ketorolac to manage pain, swelling, and trismus after third molar surgery.
Both nimesulide and ketorolac are effective analgesics and
anti-inflammatory drugs after surgical extraction of the impacted third molar.
No vital difference was noted between nimesulide and ketorolac in pain and
mouth opening.
A non-randomized trial aimed to
explore the efficacy of 100 mg nimesulide and 10 mg ketorolac to manage pain,
swelling, and trismus after third molar surgery.
Overall, 42 patients were
divided into either the nimesulide group or the ketorolac group. Both the drugs
were orally administered, instantly after extraction followed by twice daily.
Pain intensity levels (Visual Analogue Scale [VAS]), swelling, and trismus were
estimated and compared at six, 12, 24, 48, and 72 hours after surgery.
Utilizing the Mann-Whitney U test, Friedman test, and Independent t-test,
assessment of the data was done.
At various time points, no vital difference was witnessed between nimesulide and ketorolac cohorts. However, a vital difference was noted between time points within each group, as shown below:
At
various time points, there was a vital difference in mouth opening within each
cohort. The swelling was found to be more prominent in the
nimesulide-recipients compared to the ketorolac-recipients. Ketorolac
illustrated better effectiveness compared to nimesulide as an anti-inflammatory
agent after dental extractions.
Nimesulide has comparable
pain-relieving efficacy as ketorolac in patients undergoing third molar
surgery.
Journal of Nepal Dental Association
Comparison of Nimesulide and Ketorolac in Control of Pain, Swelling, and Trismus following Extraction of Impacted Third Molar
Dr. Bikash Chaudhary et al.
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