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To distinguish the relative effectiveness of various psychotropic/psychiatric drugs for the treatment of adults with functional dyspepsia (FD).
This network
meta-analysis comparing various psychotropic medicines to treat functional
dyspepsia found flupentixol + melitracen to be most effective in
relieving dyspepsia symptoms, followed by tandospirone, imipramine, and
amitriptyline.
To distinguish the relative effectiveness of various
psychotropic/psychiatric drugs for the treatment of adults with functional
dyspepsia (FD).
Database searching
included exploring Embase, PubMed, and Cochrane Library, and thereby a network
meta-analysis was conducted on the search results. Treatment efficacy was based
on the number of patients who had a definite percentage reduction in FD
symptoms or who plunged below the limit of the global overall symptom scores
were considered as the primary outcome. The secondary endpoint was
acceptability, defined as all-cause withdrawal.
As found, ten trials were eligible for analysis, which included 970 patients with FD and ten psychotropic medicines. A combination of flupentixol + melitracen (F + M), tandospirone, imipramine, and amitriptyline were found to be considerably better compared to the placebo.
As per surface under
the cumulative ranking curve (SUCRA), the most effective and least effective
treatments were F plus M (89.0%) and R137696 (13.6%), respectively. Concerning
acceptability, escitalopram was graded as the worst medicine (12.6%), which was
followed by imipramine and sertraline.
F + M, tandospirone, imipramine, and amitriptyline are
effective psychiatric
medicines for adult patients
with FD.
Medicine (Baltimore)
Comparative efficacy and acceptability of psychotropic drugs for functional dyspepsia in adults
Wan Zhou et al.
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