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A study was performed to explore the factors that impact laparoscopic fundoplication therapy efficacy in individuals suffering from erosive gastroesophageal reflux disease esophagitis, taking into consideration the findings of high-resolution manometry and multichannel intraluminal impedance pH.
In patients with erosive reflux
esophagitis, the esophageal clearance may impact the therapy outcome of
laparoscopic fundoplication.
A
study was performed to explore the factors that impact laparoscopic
fundoplication therapy efficacy in individuals suffering from erosive
gastroesophageal reflux disease esophagitis, taking into consideration the
findings of high-resolution manometry and multichannel intraluminal impedance
pH.
The
study included 102 individuals suffering from erosive gastroesophageal reflux
disease diagnosed by endoscopy, who underwent laparoscopic fundoplication as
the initial surgery. Participants were randomized into two arms: (i) A cured
arm that included subjects whose esophagitis was cured postsurgery (n=96); and
(ii) A recurrence arm included subjects who suffered recurrent esophagitis
(n=6). The findings of high-resolution manometry and the multichannel intraluminal
impedance pH were examined.
The multichannel intraluminal impedance pH
illustrated that the number of refluxes longer than five minutes, acid reflux
time, and the longest reflux time were considerably elevated in the recurrence
arm compared to the cured arm. The high-resolution manometry demonstrated that
only the distal contractile integral was remarkably reduced in the recurrence
arm.
The
number of refluxes longer than five minutes and the longest reflux time were
crucial factors impacting the therapeutic effect (considering the findings of
multichannel intraluminal impedance pH) while the distal contractile integral
value was most vital (considering the findings of high-resolution manometry) in
reflux esophagitis patients undergoing laparoscopic fundoplication.
Surgery Today
Factors affecting the treatment outcomes of laparoscopic fundoplication for erosive reflux esophagitis: findings of esophageal pathological function tests
Kazuto Tsuboi et al.
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