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To study the analgesic potential and possible link between prescription of Beta blockers and primary-care consultation in patients with knee and hip osteoarthritis (OA) and; knee and hip pain.
This large cohort study with 111,718 patients revealed that the use of
Beta blockers helped to decrease the knee OA, and knee or hip pain consultations.
The use of Atenolol and Propranolol can be used in patients with knee and hip
osteoarthritis (OA) and; knee and hip pain with particular comorbidities.
To study the
analgesic potential and possible link between prescription of Beta blockers and
primary-care consultation in patients with knee and hip osteoarthritis (OA)
and; knee and hip pain.
The Clinical Practice
Research Datalink was explored for patients aged ≥40 years with recent
Beta blockers prescriptions taken orally whose propensity score (PS) matched to
control. The Cox proportional hazard ratios (HRs) and 95% confidence intervals
(CI) were acclimatised for fractures, total primary-care consultations for
injury associated with knee or hip and; out-patient transfers and
hospitalizations in last 1 year of the cohort entry.
As per the PS matching, a total of 111
718 patients exposed to Beta blockers were matched to controls. Beta blockers
prescription was linked with decreased collective risk of knee OA (0.90
adjusted HR (95%CI)), knee pain (0.88 aHR, 95%CI), and hip pain consultations
(0.85 aHR, 95%CI).
A reduced occurence
of knee OA and knee pain consultations were prevalent in patients on
propranolol and atenolol.
Also, the Beta blockers were associated with reduced consultation for large-joint
lower-limb OA/pain mentioned as a combined effect.
The use of specific
Beta blockers can be used for musculoskeletal pain relief. Propranolol may be
appropriate therapeutic options for people with co-morbid anxiety. Atenolol can
be used in patients with co-morbidities- OA and cardiovascular in which
beta-adrenergic blocking agents are suggested.
Rheumatology
β-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study
Georgina Nakafero et al.
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