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A cross-sectional multicenter analysis was performed to investigate diagnostic performance of three test kits for detecting SARS-CoV-2 against RT-PCR.
The severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) IgM/IgG rapid test kits displayed a good diagnostic performance
and is recommended for coronavirus disease 2019 (COVID-19) diagnostics in
combination with reverse transcriptase-polymerase chain reaction (RT-PCR) to
detect the highly infected individuals.
A cross-sectional multicenter analysis was performed to
investigate diagnostic performance of three test kits for detecting SARS-CoV-2
against RT-PCR.
The performance of the test kits
was determined utilizing blood specimens against RT-PCR on the respiratory
swabs. Computation of the specificity, sensitivity, and agreement with each
other and to RT-PCR was done.
A heterogeneous comparative diagnostic performance in the specificity and sensitivity of the test kits were noted. The following table shows the sensitivity, specificity, and agreement of the test kits with RT-PCR:
A vital difference was noted in the performance among the
test kits and PCR. It aids to assess the viral seroprevalence and also the true extent of viral community
spread in resource-limited settings.
The rapid test kits in combination with RT-PCR may be used
to detect highly-infected coronavirus patients and are essential for bridging
the diagnostic gaps in community screening and healthcare facilities.
Journal of Multidisciplinary Healthcare
Diagnostic Performance of SARS-CoV-2 IgM/IgG Rapid Test Kits for the Detection of the Novel Coronavirus in Ethiopia
Abay Sisay et al.
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