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Dienogest could be considered for use in routine
clinical practice as it was well-tolerated and effectively relieved endometriosis-related
pain in women with endometriosis.
According to a recent study
published in Archives of gynecology and
obstetrics, Dienogest, a progestogen-only hormone preparation can
effectively treat the endometriosis-related pain.
Endometriosis is counted
among the most prevalent disease affecting almost 10% of women worldwide in
their childbearing age. Pharmacological treatments for endometriosis aim to
suppress ovarian function. One of such drugs is Dienogest, that works by
suppressing estradiol production and by preventing endometrium growth. However,
very little evidence is present regarding its efficacy. Therefore, a
single-center, observational and cohort study was conducted to evaluate the
efficacy of Dienogest.
A total of 132 women were
included in the study. Out of which only 21 selected for further analysis and
other got excluded due to adverse effects. The women who diagnosed with
endometriosis for more than 24 months and with endometriosis-associated pelvic
pain were involved in the study. The score of the pain among these females was
at least up to 40 mm on a 100-mm visual analogue scale (VAS) at the beginning
of the treatment. These patients were administered with 2 mg Dienogest once daily for maximum 30 days at
the time of study entry, from September 2013 to September 2014. These women
came back for their clinical pain evaluation after 1 (V1), 3 (V2), and 12 (V3)
months.
At the baseline, the VAS
score for pelvic pain was 8.9. Along with pain and other symptoms such as
dyspareunia and dyschezia were also measured through VAS score, which was 6.7
and 5.7 respectively, at the baseline. After 12-month treatment, a significant
decrease was seen in the VAS score of pain and other symptoms. The VAS score
measured was 0.9, 1.4 and 0.2 for pain, dyspareunia and dyschezia,
respectively.
The whole analysis concluded
that Dienogest (2 mg, once daily) was well adapted and effective in the
treatment of endometriosis-related pain.
Arch Gynecol Obstet. 2017 Jun 29
Efficacy of dienogest in improving pain in women with endometriosis: a 12-month single-center experience
Maiorana A et al.
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