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Low
dose cytokines could be considered a treatment of choice as cytokine therapy in
combination with standard chronic inflammatory therapy was safe and effective
in patients with chronic ulcers of lower limbs.
Venous
leg ulcers (VLUs) refer to open lesions that occur between the knee and ankle
joint in the presence of venous disease. The prevalence of chronic venous leg
ulcers has increased from 55% to 75% in 10 years. Aragona SE et al. conducted
this study to treat chronic vascular lesions according to a cyclic multiphase
method. The method follows the instrumental and differential etiologic
diagnosis of ulcers of the lower limbs.
The AIMED (Anti Inflammatory Regenerative Medicine), the operating model,
follows the diagnostic phase and is organised into five interconnected stages.
The parameters of mare evaluation, pH control, biofilm removal and prevention
and infections are commenced according to the International Guidelines.
Low-dose cytokine therapy is administrated to the patients to compare the
inflammatory process. The evaluation of chronic skin lesions in these patients
was done twice a week and treated according to the AIMED protocol. In this
study, reduction of pain at 15 and 30 days, reduction of 50% of the injury at
30 days, characteristics of perilesional skin (oedema, erythema) and global
profile of the patient were assessed as the clinical evaluation outcomes. It was deduced that the so-called low dose
cytokine therapy could change the previous therapeutic algorithms.
J Biol Regul Homeost Agents. 2017 Jul 13;31
Chronic inflammation therapy combined with low dose cytokines in the treatment of chronic ulcers of lower limbs
Aragona SE et al.
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