Nimesulide transdermal gel is a COX-2 selective, Non-Steroidal Anti-inflammatory Drug (NSAID) with analgesic properties. It is used to reduce pain and improve musculoskeletal conditions such as soft tissue injuries or non-articular rheumatic disorders.
Nimesulide transdermal gel is a COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic properties. It is used to reduce pain and improve musculoskeletal conditions such as soft tissue injuries or non-articular rheumatic disorders, including discomfort in the muscles, tendonitis, back pain, arthritis, tenosynovitis, sprains, or strains. The onset of pain relief is normally observed within 15-60 minutes.
Nimesulide inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production. Its cyclooxygenase inhibiting potency is intermediate, but is relatively selective for the cyclo-oxygenase-2 (COX-2). Thus, it has less potential for gastric injury and intolerance. Apart from its novel pharmacological features of pain control and inflammation reduction, it is also a free radical scavenger, and helps to protect against the tissue damage that occurs during inflammation.
Apply three or four times per day
Nimesulide gel is rapidly absorbed, Cmax (Maximum Peak Concentration) is reached rapidly within 120 minutes after application. Its effective concentration occurs in blood within 30 minutes after treatment and can persist for 8 hours post treatment.
Use in the following conditions is contraindicated:
Common (affecting between 1 in 10 to 1 in 100 people)
Uncommon (affecting between 1 in 100 to 1 in 1000 people)
History of alcohol abuse, colitis, crohn's disease, diverticulitis, gastric ulcer, diabetes mellitus, hemorrhoids, hepatitis, renal disease, rectal irritation or bleeding, burning sensation and tobacco abuse may increase chance of adverse effects.
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