Piroxicam is a cyclooxygenase inhibitor, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, and postoperative pain. It is used to treat the symptoms of pain and inflammation.
Piroxicam is a cyclooxygenase inhibitor, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, and postoperative pain. It is used to treat the symptoms of pain and inflammation. Its long half-life enables it to be administered once daily. It may block certain substances in the body that are linked to inflammation.
Pharmacological Class: NSAID
Piroxicam is used to reduce pain, inflammation, and stiffness caused by rheumatoid arthritis and osteoarthritis. It shows reversible inhibition of cyclooxygenase, causing peripheral inhibition of prostaglandin synthesis. Prostaglandins are produced by an enzyme called as cyclooxygenase-1 (COX-1). Piroxicam blocks the COX-1 enzyme, resulting into reduced production of prostaglandins. Piroxicam also inhibits the migration of leukocytes into inflammation sites and prevents the formation of thromboxane A2, an aggregating agent, by the platelets.
Adult dose for
Pediatric dose for
Piroxicam is well absorbed after oral administration. The volume of distribution is found to be 0.11 l/kg and plasma protein binding is 95%. Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a piroxicam dose is excreted unchanged. A substantial portion of piroxicam elimination occurs by hepatic metabolism. Piroxicam is excreted into human milk. and plasma half life is 30 to 86 hours.
Common (affecting between 1 in10 to 1 in 100)
Uncommon (affecting 1 in 100 to 1 in 1000)
Very rare (affecting less than 1 in 10,000)
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