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OA patients should be regularly assessed for any
increase in blood pressure as OA patients were at greater risk of developing
hypertension compared to patients without OA.
The recent
study data suggested that monitoring blood pressure and prescribing health
promotion interventions may be warranted among people with OA to mitigate the
potential onset and adverse consequences of hypertension. Osteoarthritis (OA)
in the large weight-bearing joints, such as in knee, is countered as a most
popular type of arthritis and one of the leading cause of disability globally.
Various research, done before has shown an association between osteoarthritis
and cardiovascular disease. But it is still not clear if there is increased
risk of developing hypertension in people suffering from osteoarthritis.
Therefore, this current study was aimed to find out this uncertainity. For this
study data of the Osteoarthritis Iniative was used. It is an ongoing public and
private longitudinal survey including people at higher risk of osteoarthritis
or having knee osteoarthritis. Knee osteoarthritis was defined through
radiological and clinical assessment. Incident hypertension was described as
systolic blood pressure >140 mmHg and a diastolic value >90 mmHg.
Multivariate Cox's regression analyses were performed, which revealed the
presence of knee osteoarthritis as the exposure and incident hypertension as
the outcome during a 96-month follow-up interval. Around 3,558 people having
normal blood pressure values at baseline were analysed (1,930 OA / 1,628
controls).
The findings estimated that within the follow-up interval, the incidence of
hypertension was noted as significantly higher in people suffering from knee
osteoarthritis as compared to those without (60/ vs 55/1,000 persons/years;
p<0.0001). It was observed, that after adjusting for 13 confounders, knee
osteoarthritis patients had a 13% higher chance of developing hypertension
(Hazard ratio = 1.13; 95%CI: 1.01-1.26, p=0.03). Propensity score analysis did
not alter these conclusions.
The study is concluded as the first longitudinal data analysis to demonstrate
that people with knee osteoarthritis are having more chance of developing
hypertension compared to those without osteoarthritis.
Rejuvenation Res. 2017 Jun 24.
Knee Osteoarthritis and Risk of Hypertension: A longitudinal cohort study
Veronese N et al.
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