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Given the absence of
suitable options for wound related pain relief in cancer and burn
patients, the use of semi-solid and fluid morphine loaded hydrogels should be
considered.
For painful wounds, MH-containing semi-solid and fluid hydrogels displayed satisfactory pharmaceutical, microbiological and physicochemical properties, making them a stable, safe and suitable for use in hospital contexts. Morphine is known for its potential benefits like dose reduction, compound formulations and fewer side effects, which make it a suitable component for wound healing.
This study developed and assessed two containing stable, sterile carboxymethylcellulose sodium-based hydrogels, comprising 1.0% w/w and 0.125% w/w morphine hydrochloride (MH) for fluid formulation ((F2-MH) and semi-solid formulation (F1-MH), respectively. The critical quality attributes (CQA) and quality target product profile (QTPP) of the hydrogels were defined using a risk assessment approach to sustain safety and product quality. Gels were translucent, homogeneous, and of yellow colour with suitable pharmaceutical and microbiological properties. The selection of active substance concentration was adjusted as per the dose-metering device characteristics. Franz diffusion cells and different kinetic models were used to examine release profiles and for characterization.
A prolonged drug
release was obtained due to increased gel viscosity, improved patient
compliance and concede for the decline of the number of applications. At room
temperature, the gel found to be stable for up to 60 days. All these findings
suggest that MH-containing gels a suitable option for pain management and wound
healing in burn and cancer palliative care patients.
Pharmaceutics
Improved Morphine-Loaded Hydrogels for Wound-Related Pain Relief
Dinis Mateus et al.
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