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Collagen supplementation improved WOMAC and VAS scores
in the patients with osteoarthritis. It can be considered as an adjuvant for
the management of osteoarthritis.
A
recently published meta-analysis in the journal- International Orthopaedics
claimed that collagen effectively improves the Osteoarthritis (OA) symptoms
decreasing both total Western Ontario and McMaster Universities Osteoarthritis
Index (WOMAC) scale and Visual Analog Scale (VAS) score.
OA is one
of the most prevalent chronic diseases which cause disability. Utilizing
collagen is on the rise due to the satisfactory results in the treatment of OA.
But, the possible beneficial effects of collagen for the treatment of OA are
presently controversial. This meta-analysis was implemented to investigate the
impact of collagen-based supplements on OA symptoms.
The
databases PubMed-Medline, Scopus, and Google Scholar, were searched for
randomized placebo-controlled trials examining the effect of orally
administered collagen on the OA symptoms. The WOMAC scale and/or the VAS were
used for the analysis.
The
meta-analysis was conducted using a Random-effects model and a Generic inverse
variance method. The I2 statistic index was used to test the heterogeneity.
The
collagen treatment depicted a significant reduction in the score of the total
WOMAC index (WMD - 8.00). The collagen supplementation revealed a substantial
decline in the stiffness subscore (WMD - 0.41), on the other hand, the pain
(WMD - 0.22) and functional limitation (WMD - 0.62) subscores did not have
significant differences. Lastly, a significant reduction was found in the VAS
score after collagen administration (WMD - 16.57).
Int Orthop.
Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials
García-Coronado JM et al.
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