EN | RU
EN | RU

Help Support

Back

New findings suggest Vitamin E's positive impact on NAFLD

NAFLD NAFLD
NAFLD NAFLD

What's new?

The use of Vitamin E in NAFLD patients is associated with improvements in ALT, AST, fibrosis, and steatosis.

A recent umbrella review of meta-analyses on randomized controlled trials suggest that Vitamin E administration holds promise in improving key nonalcoholic fatty liver disease (NAFLD) markers, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), fibrosis, and steatosis.

Fibrosis scores exhibited remarkable reductions when Vitamin E was administered at doses exceeding 600 IU/day or when treatment was sustained for a minimum of 12 months.

The primary objective was to clarify the impact of Vitamin E use on various parameters, including gamma-glutamyl transferase (GGT), ALT, AST, as well as the degrees of steatosis and fibrosis in NAFLD-affected patients. To achieve this, the research team meticulously explored databases like Web of Science, EMBASE, PubMed, SCOPUS, and MEDLINE, focusing on articles published until June 2023. Utilizing a random-effects model, the overall effect size (ES) was calculated along with confidence intervals (CI).

Six meta-analyses were scrutinized in this umbrella review, and their collective findings illustrated a promising picture. Through the synthesis of ES data using the random-effects model, it was determined that Vitamin E supplementation had a significant positive effect on several NAFLD indicators. Notably, it led to a drop in ALT, AST, degrees of fibrosis, and steatosis in patients suffering from NAFLD, as shown in Table 1:

However, it appeared to have no discernible effect on GGT levels. Digging deeper, subgroup analyses unveiled some intriguing patterns. The reduction in fibrosis scores was notably pronounced when Vitamin E dosage exceeded 600 IU/day (ES −0.25, 95% CI −0.41 to −0.10) and when the treatment duration extended to at least 12 months (ES −0.24, 95% CI −0.37 to −0.12). In conclusion, Vitamin E supplementation shows potential benefits in NAFLD.

Source:

Journal of Digestive Diseases

Article:

Vitamin E supplementation in the treatment on nonalcoholic fatty liver disease (NAFLD): Evidence from an umbrella review of meta-analysis on randomized controlled trials

Authors:

Ming Yue Wang et al.

Comments (0)

You want to delete this comment? Please mention comment Invalid Text Content Text Content cannot me more than 1000 Something Went Wrong Cancel Confirm Confirm Delete Hide Replies View Replies View Replies en ru
Try: