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Prenatal carotenoid (particularly lutein and zeaxanthin) supplementation may boost maternal and infant health by improving systemic carotenoid status.
In an exciting development for expectant mothers and their babies, an innovative study, known as the Lutein and Zeaxanthin in Pregnancy (L-ZIP) Randomized Trial, has demonstrated the remarkable benefits of prenatal carotenoid supplementation. The trial, which aimed to investigate the impact of carotenoid intake on maternal and infant health, has provided compelling evidence for the positive effects of these micronutrients.
A total of 47 pregnant women in their first trimester were randomized to two groups using a random allocation method: one group received standard-of-care prenatal vitamins along with a softgel containing 10 mg of lutein and 2 mg of zeaxanthin (the carotenoid group), while the other group received standard-of-care prenatal vitamins along with a placebo softgel (the control group) for a period of six-eight months.
High-performance liquid chromatography and resonance raman spectroscopy were utilized to measure the concentrations of carotenoids in the serum and skin of mothers. These measurements were taken at the conclusion of each trimester and postpartum. For infants, similar techniques were used, but optimized for their age. Repeated measures and paired t-tests were carried out, and statistical significance was set at P < 0.05. Following supplementation, the carotenoid group showed a considerable rise in maternal serum concentrations of lutein + zeaxanthin, total carotenoids, and skin carotenoid status compared to the control group at all time points.
As found, infants born to mothers in the carotenoid group had a substantial 5-fold elevation in cord blood concentrations of lutein + zeaxanthin, a more than 3-fold rise in cord blood total carotenoids, and a 38% elevation in skin carotenoids in comparison with the control group. Furthermore, a robust positive link was witnessed between the systemic carotenoid status of mothers after childbirth and that of their infants.
Prenatal carotenoid supplementation holds tremendous promise for enhancing the systemic carotenoid status (skin and serum) of both expectant mothers and infants, potentially contributing to improved health outcomes. These promising results open doors for potential advancements in prenatal care, ensuring healthier outcomes for both mothers and their children As awareness grows about the importance of prenatal nutrition, this research paves the way for a new era of targeted interventions, ultimately shaping healthier futures for mothers and their precious little ones.
The Journal of Nutrition
Systemic Effects of Prenatal Carotenoid Supplementation in the Mother and her Child: The Lutein and Zeaxanthin in Pregnancy (L-ZIP) Randomized Trial -Report Number 1
Emmanuel K Addo et al.
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