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Dextrose prolotherapy, a proliferation injection
therapy shows a positive trend towards the management of TMJ hypermobility.
Within the constraints, this regenerative injection therapy using dextrose leads to a considerable reductions in pain and mouth opening, two of the most prevalent symptoms of TMJ hypermobility. To evaluate these outcomes, a systematic review and meta-analysis was conducted that involves the data of controlled clinical trials (CCTs) and Randomised clinical trials (RCTs), extracted from CENTRAL, scopus, pubmed and google scholar databases.
In total three RCTs
were included for the analysis, exhibited a considerable difference in Maximal
mouth opening (MMO) on pooling of data and reduction in pain as compared to the
placebo. However, the inter-group difference between the groups regarding pain
was negligible. Finally, the difference between the dextrose and placebo
regarding the frequency of sulbluxation/dislocation was negligible. Findings in
relation to decline episodes of
sulbluxation/dislocation cannot be pulled at this point. Further
assessments of more high quality RCTs with homogenous prolotherapy and larger
sample size are required.
J Oral Rehabil. 2018 Jul 19.
The efficacy of dextrose prolotherapy over placebo for temporomandibular joint hypermobility: a systematic review and meta-analysis
Nagori SA et al.
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