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Botulinum toxin A or hyaluronate
injection followed by therapeutic exercise provides clinicians with a new
treatment option for pain management in patients with knee OA.
Therapeutic exercise after
intra-articular injection of botulinum toxin type A or hyaluronate injection
resulted in significant improvement in pain and knee functioning in patients
with knee OA, according to the study published in 'Journal of Rehabilitation
Medicine'.
Xiao BAO et al. and his colleagues
conducted a randomized controlled trial to study the effect of therapeutic
exercises performed after the injection of botulinum toxin type A, hyaluronate
or saline in knee OA patients.
A total of 60 patients with knee OA were randomly enrolled to 3 groups: Group A (injected with saline), Group B (injected with botulinum toxin A) and Group C (injected with hyaluronate). All the participants were asked to perform therapeutic exercise after injection. Visual Analogue Scale (VAS) score, Western Ontario and McMaster Universities Osteoarthritis Index questionnaire (WOMAC) score and Medical Outcomes Study 36-item Health Survey (SF-36)score were calculated at baseline and the end of 4th and 8th weeks.
The scores on the WOMAC and VAS scale were higher in the control group at the end of 4th and 8th week. Significant differences were observed in Mental Component Summary-36 scores (MCS-36) and Physical Component Summary-36 (PCS-36) between the 3 groups at the end of the 4th and 8th weeks. No significant differences were observed in MCS-36 and PCS-36 between groups A and C at the end of the 4th week. There were no significant changes observed in MRI and X-ray images of affected knees after the intervention.
The study findings suggested that
therapeutic toxin following a botulinum toxin A or hyaluronate injection is
effective for knee OA management. However, the efficacy of botulinum toxin A
plus therapeutic exercise was more than hyaluronate injection plus therapeutic
exercise.
Department of Rehabilitation Medicine
Effect of therapeutic exercise on knee osteoarthritis after intra-articular injection of botulinum toxin type A, hyaluronate or saline: A randomized controlled trial.
Bao X. et al.
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