EN | RU
EN | RU

Help Support

Back

Vonoprazan found to have lower post-ESD bleeding rate

Vonoprazan found to have lower post-ESD bleeding rate Vonoprazan found to have lower post-ESD bleeding rate
Vonoprazan found to have lower post-ESD bleeding rate Vonoprazan found to have lower post-ESD bleeding rate

What's new?

Compared to PPIs, vonoprazan illustrates a decreased post-ESD bleeding rate.

According to the findings of a retrospective cohort study published in Gastrointestinal Endoscopy, vonoprazan may be suggested for post-endoscopic submucosal dissection (ESD) bleeding in the stomach since it exhibits a lower bleeding rate when compared to proton pump inhibitors (PPIs).

This nationwide population-based study was carried out to examine the post-ESD bleeding rates between PPIs and vonoprazan. The study involved nine hospitals. Following two days of intravenous administration of PPI, either vonoprazan or PPI was given from postsurgery day 2 to day 30.

Overall, data of 1,715 participants (627 patient pairs) were assessed through propensity score matching in this multicentre study. The vonoprazan group exhibited remarkably reduced post-ESD bleeding rates and reduced readmission rate due to post-ESD bleeding compared to the PPI group, as shown in Table 1:


Both the groups demonstrated comparable blood transfusion and additional surgery because of delayed perforation. In both groups, no deaths were reported to occur within 30 days. On the Cox regression assessment, direct oral anticoagulant usage, vonoprazan usage, lesion location (antrum), Charlson Comorbidity Index (≥2), and aspirin usage were linked with a raised risk of post-ESD bleeding within 30 days.

Vonoprazan seems to be beneficial for minimizing the post-ESD bleeding rate. However, there is a requirement for future prospective studies to validate these outcomes. 

Source:

Gastrointestinal Endoscopy

Article:

Vonoprazan versus proton pump inhibitors for postendoscopic submucosal dissection bleeding in the stomach: a multicenter population-based comparative study

Authors:

Yasutoshi Shiratori et al.

Comments (0)

Recommendations

You want to delete this comment? Please mention comment Invalid Text Content Text Content cannot me more than 1000 Something Went Wrong Cancel Confirm Confirm Delete Hide Replies View Replies View Replies en ru ua
Try: