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Analgesic effectiveness of magnesium sulphate and bupivacaine for arthroscopy

Analgesic effectiveness of magnesium sulphate and bupivacaine for arthroscopy Analgesic effectiveness of magnesium sulphate and bupivacaine for arthroscopy
Analgesic effectiveness of magnesium sulphate and bupivacaine for arthroscopy Analgesic effectiveness of magnesium sulphate and bupivacaine for arthroscopy

A study was conducted to determine efficacy of magnesium sulphate + bupivacaine for arthroscopy.

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Key take away

For conducting arthroscopy, combination analgesia with magnesium sulphate plus bupivacaine offers better alleviation of pain when compared to bupivacaine alone.

Background

A study was conducted to determine efficacy of magnesium sulphate + bupivacaine for arthroscopy.

Method

In this systematic review and meta-analysis, databases like Embase, Cochrane Library, PubMed, EBSCO, and Web of science were explored for the relevant randomized controlled trials (RCTs) that determined the effect of magnesium sulphate + bupivacaine vs bupivacaine for arthroscopy.

A random-effect model was used for carrying out this meta-analysis. Pain scores and duration of analgesia were the primary endpoints while analgesic consumption, first time to analgesic need, and nausea and vomiting were the secondary endpoints. 

Result

Overall, 6 RCTs were incorporated. In comparison with bupivacaine alone, magnesium sulphate in combination with bupivacaine was linked with considerably extended duration of analgesia (standard mean difference [SMD] = 0.93) and first time to analgesic need (SMD=196.57), decreased pain scores (SMD=-1.71) and minimized analgesic consumption (SMD=-1.04). However, no significant influence was noted on nausea or vomiting (OR=1.54).

Conclusion

Magnesium sulphate in combination with bupivacaine can substantially enhance the pain-relieving effectiveness for arthroscopy.

Source:

The Journal of Orthopaedic Surgery and Research

Article:

The effect of magnesium added to bupivacaine for arthroscopy: a meta-analysis of randomized controlled trials

Authors:

Weineng Xiang et al.

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