Assessment of hospitalization risk in patients with SARS-CoV-2 and Type 1 Diabetes

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Created On: 08/12/2021

Assessment of hospitalization risk in patients with SARS-CoV-2 and Type 1 Diabetes

A cross-sectional study was carried out for quantifying the risk for SARS-CoV-2-linked hospitalization and deleterious outcomes by age in individuals suffering from type 1 diabetes and lab-confirmed coronavirus infection.

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Key take away

Age greater than forty years was linked with the highest risk for hospitalization in individuals with type 1 diabetes and coronavirus disease.

Background

Method

In this observational, multisite study, an examination of the distribution of participant factors and outcomes across the age groups (> 40, 19-40, and 0-18 years) was done. For describing the study population, descriptive statistics were utilized. For analyzing the association between hospitalization, age, and detrimental outcomes, multivariate logistic regression models were utilized. Hospitalization for coronavirus disease was the major endpoint.

Result

Overall, 767 participants were examined. Overall, 14% (n = 105) were aged more than forty years, 32% (n = 247) were aged nineteen to forty years, and 54% (n = 415) were aged 0 to eighteen years. Notably, 170 participants were hospitalized, and five participants died.

In comparison with the 0- to 18-years age group, participants aged more than forty years exhibited an adjusted odds ratio of 4.2 for hospitalization after adjusting for comorbidities, glycated hemoglobin A1c, gender, race, and insurance type.

Conclusion

For individuals diagnosed with diabetes and coronavirus disease, age older than forty years is a risk factor. However, younger adults and children report milder disease and superior prognosis. This denotes a requirement for age-tailored therapies, clinical management, and immunization of people affected by type 1 diabetes.