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Association between Homocysteine, Folate, and risk of NAFLD

Homocysteine Homocysteine
Homocysteine Homocysteine

A systematic review and meta-analysis investigated the link between circulating levels of Homocysteine and Folate and risk of NAFLD development.

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Key take away

Serum Homocysteine and NAFLD risk have a positive correlation, whereas serum Folate and NAFLD risk have an inverse correlation.

Background

A systematic review and meta-analysis investigated the link between circulating levels of Homocysteine and Folate and risk of NAFLD development.

Method

A meta-analysis of observational studies collected from three databases was conducted to assess the correlations. In order to strengthen the causal inference, Mendelian randomization analysis was executed. From two meta-analyses of genome-wide association studies (GWASs) of 44,147 and 37,645 people with European ancestry, independent single-nucleotide polymorphisms without linkage disequilibrium that were actively linked with serum Homocysteine and Folate levels were chosen as instrumental variables, respectively.

A GWAS of 8434 NAFLD-affected patients and 770,180 controls with European ancestry provided information on NAFLD. From a GWAS of 361,194 people with European descent, four liver enzymes as secondary endpoints were included.

Result

The meta-analysis included 22 observational studies (30,368 volunteers). NAFLD risk and serum Homocysteine were positively correlated (odds ratio [OR]: 1.96; n = 20), but NAFLD risk and serum Folate were inversely correlated (OR: 0.75; n = 12).

The ORs of NAFLD in the MR analysis were 0.75 and 1.17 per 1-SD increase of genetically predicted circulating Folate and Homocysteine concentrations, respectively. Each 1-SD elevation in circulating Folate and Homocysteine levels genetically predicted was associated with alterations in ALT concentrations of -0.84 U/L and 0.62 U/L, respectively.

Conclusion

Future clinical research on the possibility of reducing Homocysteine concentrations for prophylaxis of NAFLD is necessary given the probable role of circulating Homocysteine and possibly Folate in the disease.

Source:

The American Journal of Clinical Nutrition

Article:

Homocysteine, Folate, and nonalcoholic fatty liver disease: a systematic review with meta-analysis and Mendelian randomization investigation

Authors:

Shuai Yuan et al.

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