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The clinical efficacy (particularly recovery time) of 95% effective dose (ED95) of butorphanol and sufentanil in GI endoscopy has been distinguished in this double-blind, randomized study.
Butorphanol is an analgesic which is commonly used for the
management of perioperative pain. In comparison with sufentanil, butorphanol when used along with propofol as anesthesia
for GI endoscopy proved to be an outstanding sedation approach which lessens
the recovery time.
The clinical efficacy (particularly recovery
time) of 95% effective dose (ED95) of butorphanol and sufentanil in
GI endoscopy has been distinguished in this double-blind, randomized study.
The study have into divided into 2 sections,
i.e. in the first section, the voluntary patients who needed GI endoscopy
anesthesia were enrolled to calculate the ED95 of butorphanol
and sufentanil needed to achieve successful sedation prior to GI endoscopy via
Dixon up-and-down method (sequential method).
The second section was a randomized study comprising of 200 cases of painless
GI endoscopy patients, randomly allocated in 2 groups (100 patients each) as group
B (butorphanol at ED95 dose) and group S (sufentanil at ED95 dose).
Propofol was used as a sedative given intravenously in both the groups. Fatigue
severity scores, time of recovery, visual analogue scale (VAS), hand grip
strength, occurrence of nausea, vomiting and dizziness noted carefully.
Butorphanol and sufentanil at ED95 dose for
painless GI endoscopy was found to be 9.07 μg/kg (95% confidence interval:
7.81–19.66 μg/kg) and 0.1 μg/kg (95% CI, 0.079–0.422 μg/kg), respectively. Both
of these were good analgesics for GI endoscopy. But, butorphanol had a
significantly shorter recovery time as compared to sufentanil (21.26 ± 7.70
versus 24.03 ± 7.80 min).
As concluded, butorphanol 9.07 μg/kg more efficiently
provided GI endoscopy sedation as compared to sufentanil.
BMC Anesthesiology
Comparison of ED95 of Butorphanol and Sufentanil for gastrointestinal endoscopy sedation: a randomized controlled trial
Xiaona Zhu et al.
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