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Clinical outcomes in patients prescribed Cannabis for post-traumatic stress disorder

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General comorbid situation General comorbid situation

An observational study aimed to investigate alterations in health-related quality of life (HRQoL) and adverse events in subjects who were administered Cannabis-based medicinal products (CBMPs) for post-traumatic stress disorder (PTSD) management.

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Key take away

Cannabis-based medicinal product treatment is associated with improvements in post-traumatic stress disorder-specific symptoms, sleep, health-related quality of life, and anxiety at up to six months.

Background

An observational study aimed to investigate alterations in health-related quality of life (HRQoL) and adverse events in subjects who were administered Cannabis-based medicinal products (CBMPs) for post-traumatic stress disorder (PTSD) management.

Method

A patient case-series from the UK Medical Cannabis Registry was examined. With the use of validated patient-reported outcome measures (PROMs), HRQoL was evaluated after one, three, and six months. The Common Terminology Criteria for Adverse Events version 4.0 was used to examine adverse events. The statistical significance was characterized as p < 0.050.

Result

Among the 162 patients that were incorporated, 144 (88.89%) patients were current or former Cannabis users. The median daily Cannabidiol and Δ9-tetrahydrocannabinol doses for the CBMP were 5.00 (IQR: 0.00-70.00) mg and 145.00 (IQR: 100.00-200.00) mg, respectively. Across all follow-up periods, there were significant enhancements in anxiety, sleep quality, and PTSD symptoms (p < 0.050).

As found, 20.37% of subjects (n = 33) experienced 135.8% (n = 220) adverse events, which were categorized as mild or moderate in severity (n = 190, 117.28%). The most frequent symptoms were insomnia and fatigue (n = 20, 12.35%).

Conclusion

Patients who started CBMP treatment experienced enhancements in HRQoL. Analysis of adverse events indicated acceptance and safety for up to six months. This research may help randomized placebo-controlled studies, which are necessary to determine causality and establish the optimal dosage.

Source:

Expert Review of Neurotherapeutics

Article:

Assessment of clinical outcomes in patients with post-traumatic stress disorder: analysis from the UK Medical Cannabis Registry

Authors:

Manaswini Pillai et al.

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