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To examine the safety and efficacy of a synbiotic mixture of probiotic and prebiotic therapy for CSU.
This randomized controlled study found the
adjuvant use of a mixture of probiotic and prebiotic therapy to be effective in
improving the quality of life in patients with chronic spontaneous urticaria
(CSU).
To examine the safety and efficacy of a
synbiotic mixture of probiotic and prebiotic therapy for CSU.
Overall, 42 patients with CSU were randomized as
(i) Intervention group (21 patients) receiving antihistamine and probiotic and;
(ii) Control group (21 patients) receiving antihistamine alone for 8 weeks.
Urticaria Activity Score (UAS7) and Persian validated Dermatology Life Quality
Index (DLQI) were utilized to examine the efficacy and patient's quality of
life, respectively.
Statistically significant decline in UAS7 score and improvement in DLQI score was observed in both the groups, as shown in the table below:
Probiotics are safe
and effective adjunct therapy for patients with CSU with a high rate of
satisfaction. As per the UAS7 score, the combo of probiotic and antihistamines
had no considerable difference in efficacy when compared with antihistamines
alone. However, these patients may experience greater reductions in itch, the
number of urticaria, and overall UAS7 score along with improved DLQI score.
European Annals of Allergy and Clinical Immunology
Probiotic as an adjuvant therapy in chronic urticaria: a blinded randomized controlled clinical trial
N Atefi et al.
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