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This study aimed to explore the effect of NSPT on rheumatoid arthritis activity, periodontal status, and levels of biomarkers in plasma and saliva of people suffering from rheumatoid arthritis and periodontitis.
Nonsurgical periodontal
treatment (NSPT) is an effective
approach to improve the clinical status of rheumatoid arthritis and
periodontitis patients. Also, it results in reduction of concentration of
survivin and RANKL in saliva and plasma.
This study
aimed to explore the effect of NSPT on rheumatoid arthritis activity,
periodontal status, and levels of biomarkers in plasma and saliva of people
suffering from rheumatoid arthritis and periodontitis.
In this short-term controlled clinical trial, 66 participants were segregated into three groups: (i) People without periodontitis and rheumatoid arthritis (n=19), (ii) People without periodontitis and with rheumatoid arthritis (n=23), and (iii) People with periodontitis and rheumatoid arthritis (n = 24).
Evaluation of
the Disease Activity Score (DAS-28) assessment, full-mouth periodontal clinical
check up, and detection of receptor activator of nuclear factor kappa-Β ligand
(RANKL), osteoprotegerin (OPG), RANKL/OPG, and survivin in plasma and saliva
were carried out at baseline (T1) and 45 days following NSPT (T2).
In people with periodontitis and rheumatoid arthritis, NSPT demonstrated efficacy in improving the periodontal condition. At T2, considerable decline in DAS-28 were witnessed in people with periodontitis and rheumatoid arthritis. A remarkably elevated levels of survivin and RANKL were noted in the saliva and plasma from rheumatoid arthritis individuals (with and without periodontitis) in comparison with controls.
Furthermore, survivin and RANKL illustrated positive
correlations with DAS-28 and a considerable decline at T2 in people with
periodontitis and rheumatoid arthritis.
NSPT effectively improves the
clinical status of both periodontitis and rheumatoid arthritis
people, and also decreases the concentration of biomarkers like RANKL and
survivin in plasma and saliva.
Clinical oral investigations
Nonsurgical periodontal therapy decreases the severity of rheumatoid arthritis and the plasmatic and salivary levels of RANKL and Survivin: a short-term clinical study
Marcela Faria Moura et al.
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