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This randomized, double-blind research is based on comparison of oxycodone and sufentanil in terms of pain relief and side effects associated with transition analgesia and PCIA following gynecological (gynae) tumor surgery.
Gynecological tumor surgery often causes
acute postoperative pain, lengthy hospital stays, along with poor patient
satisfaction.
Sufentanil patient-controlled intravenous
analgesia (PCIA) by the means of background infusion and oxycodone PCIA minus
the background infusion was used in this study which revealed no disparity
in rescue analgesia rate in post-anesthesia care unit in all the 4 groups. Also,
oxycodone produced less adverse issues and lesser opioid use than sufentanil.
This randomized, double-blind
research is based on comparison of oxycodone and sufentanil in terms of pain
relief and
side effects associated with transition analgesia and PCIA following
gynecological (gynae) tumor surgery.
The patients undertaking
the elective gynae tumor surgery were randomized into 4 groups as:
The Numerical Rating Scale (NRS) at rest and coughing,
opioid use during PCIA and patients’ satisfaction were regarded as primary
outcomes
After the surgery, Group OS and Group O patients
had a shorter duration of consciousness recovery (3.65 ± 2.51 p<0.0083,
Group OS vs. Group SO and 3.82 ± 2.67) and extubation (5.24 ± 3.02 p<0.0083,
Group OS vs. Group SO and 5.35 ± 2.94 ). Opioid use in PCIA (morphine
equivalents) in Group SO and Group O was notably less [7 (3.5,12) and 7 (0,16)]
in comparison with Group S and Group OS [120 (110,136) p<0.0083, Group OS
vs. Group SO; p<0.0083, Group S vs. Group O and 126 (116,140) p<0.0083,
Group OS vs. Group SO; p<0.0083, Group OS vs. O]. At rest and coughing,
lower NRS and more patient’ satisfaction at 3 hours, 1 day and 2 days was
observed in Group O patients. Shorter intestinal recovery time was observed in
Group SO and group O patients.
Both the opioid medications, oxycodone and
sufentanil offered suitable pain relief in transitional analgesia and PCIA
treatment after surgery. Less analgesic drug use and quicker recovery was
observed in oxycodone without background infusion as compared to sufentanil by
using background infusion in PCIA following gyne tumor operation under
anesthesia.
Dovepress
Oxycodone vs Sufentanil in Patient-Controlled Intravenous Analgesia After Gynecological Tumor Operation: A Randomized Double-Blind Clinical Trial
Sha-Jie Dang et al.
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