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Due to analgesic and
mood-modulating effects, melatonin should be recommended as an adjuvant
therapy for the management of FM symptoms.
According to the research conducted by the University of Extremadura Spain, melatonin reduces the cortisol and anxiety levels with enhanced mood and quality of life among fibromyalgia patients. As the fibromyalgia associated with mood disturbances, the analysis aimed to evaluate the effect of varying doses of Melatonin on mood status, cortisol levels, quality of life and anxiety among fibromyalgia patients.
Patients received different doses of Melatonin for ten straight days, with placebo given during the ten days either prior to or between Melatonin doses after a 10-day baseline period for the collection of data. The Numerical Pain Scale (NPS), Visual Analog Scale (VAS), the State-Trait Anxiety Test (STAI), the Fibromyalgia Impact Questionnaire (FIQ), the Short Form-36 Health Survey (SF-36) and enzyme-linked immunoassay were used to measure the pain, anxiety, mood, quality of life and urinary cortisol levels.
Melatonin at a dose
of 9mg, 12mg and 15mg were linked with reduced NPS, FIQ total scores and
urinary cortisol levels whereas, STAI scores improved after 12 mg of Melatonin,
VAS and SF-36 after 9 mg of dose. All these findings display a significant role
of Melatonin in improving the health of fibromyalgia patients.
Biol Res Nurs
Melatonin Improves Mood Status and Quality of Life and Decreases Cortisol Levels in Fibromyalgia.
M. Yolanda Castaño et al.
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