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Knee osteoarthritis (OA) is a prevalent arthritis condition among adult people.
Knee osteoarthritis is a
prevalent arthritis condition, which demands more than NSAIDs and this study
involved the clinical and radiographical evaluation of one of the natural
method, Leukocyte-poor platelet-rich plasma for management of osteoarthritis
and results affirm that these injections are better for clinical improvement
with respect to HA injections or oral NSAIDs in the treatment of
osteoarthritis.
Knee osteoarthritis (OA) is a
prevalent arthritis condition among adult people. Intra-articular injections
[platelet-rich plasma (PRP)] or hyaluronic acid (HA)] or nonsteroidal
anti-inflammatory drugs (NSAID) can give a significant clinical advantage.
Furthermore, the magnetic resonance imaging (MRI) is a useful tool to determine
cartilage thickness and volume in knee osteoarthritis. The study was aimed to
assess the PRP injection advantage than with NSAID and hyaluronic acid in knee
OA patients and to compare the radiographic progression at the 52-week
follow-up.
A total of 106 patients were
recruited and randomized into three groups (PRP, NSAIDs, and HA) as per the
Spanish Rheumatology Society knee osteoarthritis diagnosis criteria. Out of
106, only 98 completed the analysis. Using visual analogue scale (VAS) and
Western Ontario McMaster Universities osteoarthritis index (WOMAC), patients
were prospectively assessed at baseline, 26 and 52 weeks. Further, X-ray and
MRI used to evaluate patients at baseline and 52 weeks.
The 24 and 30% of patients of PRP group at the
52-week follow-up exhibited an improvement in functionality and 20% reduction
in WOMAC pain, respectively. The hyaluronic acid and NSAID groups showed an
improvement in VAS and WOMAC scores. Still, the PRP group exhibited better
outcomes than other groups. The differences were noticed in cartilage thickness
or Kellgren-Lawrence progression.
Leukocyte-poor PRP injections are
beneficial in terms of clinical improvement than oral NSAIDs or HA injections
in knee OA treatment at the 52-week follow-up. Furthermore, a single LP-PRP
injection shows a significant efficacy but does not induce cartilage
progression.
J Orthop Traumatol
Clinical and radiographic comparison of a single LP-PRP injection, a single hyaluronic acid injection and daily NSAID administration with a 52-week follow-up: a randomised controlled trial.
David Buendía-López et al.
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