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To present data about the impact of vitamin D supplementation on symptomatic knee osteoarthritis (OA).
Knee osteoarthritis (OA) is the most common joint disorder in
elderly individuals, with a prevalence of 10% in men and 13% in women ages 60
years or older. This knee OA will eventually will go on to have a total knee
replacement. Therefore this meta analysis suggested vitamin D
supplementation, a cost-effectiveness
approach to prevent the progression of knee OA.
To present data about the impact of vitamin D
supplementation on symptomatic knee osteoarthritis (OA).
A systematic review and meta-analysis were performed to
pool the results from randomised clinical trials quantitatively. MEDLINE, Web of Science, conference abstracts,
reference lists of identified studies,
Embase, and ClinicalTrials.gov were searched to collect the data.
Assessment of effect sizes were done by applying a standardised mean difference
(SMD). Fixed-effects or random-effects models were employed to pool outcomes
depending on the degree of heterogeneity.
A total of four clinical trials comprising 560 subjects
in the placebo group and 570 subjects in
the vitamin D supplementation group were selected. All of the selected studies
were of high quality and low risk of bias. According to the outcomes, vitamin D
supplementation had a statistically notable but small-to-moderate impact on
pain control among the patients with knee OA. Although, no effects were noticed
for the joint space width or change in tibial cartilage volume. Further, as per
the subgroup analysis, vitamin D showed no notable impact regardless of whether
patients had enough or inadequate serum 25(OH) D levels at baseline.
Vitamin D supplementation may not have a clinically
notable influence on structure progression or pain management within
participants with knee OA. Longer-term clinical trials with the correct
judgment of symptom and radiologic changes are needed to further elucidate the
influence of vitamin D supplementation among individuals with symptomatic knee
OA and low serum 25(OH)D levels.
Clinical Biochemistry
Effect of vitamin D supplementation on knee osteoarthritis: A systematic review and meta-analysis of randomized clinical trials
Naicheng Diao et al.
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