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Safety and efficacy of Bisphosphonates to alleviate secondary childhood osteoporosis

Osteoporosis Osteoporosis
Osteoporosis Osteoporosis

To investigate the effectiveness and safety of Bisphosphonates in treating secondary childhood osteoporosis, a meta-analysis was conducted.

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Key take away

In children with secondary osteoporosis, the use of Bisphosphonates is effective and safe.

Background

To investigate the effectiveness and safety of Bisphosphonates in treating secondary childhood osteoporosis, a meta-analysis was conducted.

Method

In order to find out randomized clinical trials (RCTs) on Bisphosphonate therapy for childhood secondary osteoporosis, databases like Web of Science, Cochrane library, and PubMed were explored. Data was retrieved and evaluated from a few studies, namely alterations in lumbar spine (LS) bone mineral density (BMD) Z-scores, adverse events, fracture events, and alterations in LS BMD.

Result

The meta-analysis included 9 RCTs (n = 429). According to the meta-analysis, bisphosphonates enhanced the alterations in LS BMD Z-scores [mean difference (MD)=0.52] and LS BMD [MD=0.04]. The probability of adverse events [odds ratio (OR)=1.61] was not increased by the utilization of Bisphosphonates.

Subgroup analysis revealed that the effectiveness of Bisphosphonates may be influenced by the routes of administration, but not by the causes of secondary osteoporosis. The incidence of fracture (OR = 0.34) was nearly considerably enhanced by intravenous (IV) Bisphosphonates.

Conclusion

The therapeutic utility of Bisphosphonates in secondary childhood osteoporosis is supported by  the improvement of LS BMD without a rise in rates of adverse events. More substantial RCTs are still necessary, particularly in light of their long-term implications on fracture rates.

Source:

Therapeutic Advances in Chronic Disease

Article:

Efficacy and safety of bisphosphonates on childhood osteoporosis secondary to chronic illness or its treatment: a meta-analysis

Authors:

Huawei Zhao et al.

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